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1

3. Diagnosis and Treatment of Thyroid Diseases; 3．甲状腺疾患の診断と治療;

Akamizu, Takashi

Journal:

Nihon Naika Gakkai Zasshi

Year:

2017

File:

PDF, 298 KB

2017

2

Ghrelin for cachexia

Takashi Akamizu, Kenji Kangawa

Journal:

Journal of Cachexia, Sarcopenia and Muscle

Year:

2010

Language:

english

File:

PDF, 175 KB

english, 2010

3

Comprehensive research on thyroid diseases associated with autoimmunity: autoimmune thyroid diseases, thyroid diseases during immune-checkpoint inhibitors therapy, and immunoglobulin-G4-associated thyroid diseases

Inaba, Hidefumi, Ariyasu, Hiroyuki, Takeshima, Ken, Iwakura, Hiroshi, Akamizu, Takashi

Journal:

Endocrine Journal

Year:

2019

Language:

english

File:

PDF, 1.05 MB

english, 2019

4

Cloning of a human immunoglobulin gene fragment containing both VH-D and D-JH rearrangements: Implication for VH-D as an intermediate to VH-D-JH formation

Euy Kyun Shin, Fumihiko Matsuda, Junji Fujikura, Takashi Akamizu, Hideo Sugawa, Toru Mori, Tasuku Honjo

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 343 KB

english, 1993

5

Generation of a transgenic animal model of hyperthyroid Graves' disease

Misa Kim-Saijo, Takashi Akamizu, Koichi Ikuta, Yasuhiko Iida, Katsuyuki Ohmori, Kazumi Matsubara, Yoichi Matsuda, Misao Suzuki, Fumihiko Matsuda, Kazuwa Nakao

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

6

Association study of autoimmune thyroid disease at 5q23-q33 in Japanese patients

Takashi Akamizu, Hitomi Hiratani, Satoshi Ikegami, Stephen S. Rich, Donald W. Bowden

Journal:

Journal of Human Genetics

Year:

2003

Language:

english

File:

PDF, 191 KB

english, 2003

7

Association of the T-cell regulatory geneCTLA4with Graves’ disease and autoimmune thyroid disease in the Japanese

Koichi Furugaki, Senji Shirasawa, Naofumi Ishikawa, Kunihiko Ito, Koichi Ito, Sumihisa Kubota, Kanji Kuma, Hajime Tamai, Takashi Akamizu, Hitomi Hiratani, Masao Tanaka, Takehiko Sasazuki

Journal:

Journal of Human Genetics

Year:

2004

Language:

english

File:

PDF, 170 KB

english, 2004

8

Acylated ghrelin level in patients with OSA before and after nasal CPAP treatment

Ken-ichi TAKAHASHI, Kazuo CHIN, Takashi AKAMIZU, Satoshi MORITA, Kensuke SUMI, Toru OGA, Hisako MATSUMOTO, Akio NIIMI, Tomomasa TSUBOI, Shunichi FUKUHARA, Kenji KANGAWA, Michiaki MISHIMA

Journal:

Year:

2008

Language:

english

File:

PDF, 119 KB

english, 2008

9

EFFECTS OF GHRELIN TREATMENT ON PATIENTS UNDERGOING TOTAL HIP REPLACEMENT FOR OSTEOARTHRITIS: DIFFERENT OUTCOMES FROM STUDIES IN PATIENTS WITH CARDIAC AND PULMONARY CACHEXIA

Takashi Akamizu, Hiroshi Iwakura, Hiroyuki Ariyasu, Toshinori Murayama, Eriko Sumi, Satoshi Teramukai, Koji Goto, Eijiro Ohnishi, Haruhiko Akiyama, Keiichi Kawanabe, Manabu Nankaku, Noriaki Ichihashi,

Journal:

Journal of the American Geriatrics Society

Year:

2008

Language:

english

File:

PDF, 81 KB

english, 2008

10

Cardiomyopathy associated with Graves' disease

Hiroyuki Koshiyama, Donald F. Sellittl, Takashi Akamizu, Sonia Q. Doi, Yuzou Takeuchi, Dalsuke Lnoue, Hiromi Sakaguchl, Genzou Takemura, Yuklhlto Sato, Yoshiki Takatsun, Kazuwa Nakao

Journal:

Clinical Endocrinology

Year:

1996

Language:

english

File:

PDF, 1.69 MB

english, 1996

11

Biological effect of anti-fucosyl GM1 ganglioside antibody on cyclic adenosine 3′,5′-monophosphate production in FRTL5 rat thyroid cells

Shinji Kosugi, Takashi Akamizu, Masumi Miyamoto, Hideo Sugawa, Masao Iwamori, Yoshitaka Nagai, Toru Mori, Hiroo Imura

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 1015 KB

english, 1987

12

A microsequencing approach to identify proteins which appear to interact with thyrotropin in rat FRTL-5 thyroid cells

Takashi Akamizu, Motoyasu Saji, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 1.37 MB

english, 1990

13

Thyrotropin receptor processing and interaction with thyrotropin

Takashi Akamizu, Shinji Kosugi, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 1.40 MB

english, 1990

14

Increases in cytosolic Ca++ down regulate thyrotropin receptor gene expression by a mechanism different from the cAMP signal

Motoyasu Saji, Shoichiro Ikuyama, Takashi Akamizu, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 1.22 MB

english, 1991

15

Prokaryotic expression of the thyrotropin receptor and identification of an immunogenic region of the protein using synthetic peptides

Osamu Takai, Rajesh K. Desai, G.S. Seetharamaiah, Craig A. Jones, Graham P. Allaway, Takashi Akamizu, Leonard D. Kohn, Beller S. Prabhakar

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 737 KB

english, 1991

16

Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: Effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies

Shinji Kosugi, Toshiaki Ban, Takashi Akamizu, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 976 KB

english, 1992

17

The physiological significance and potential clinical applications of ghrelin

Takashi Akamizu, Kenji Kangawa

Journal:

European Journal of Internal Medicine

Year:

2012

Language:

english

File:

PDF, 197 KB

english, 2012

18

Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect

Takashi Akamizu, Kenji Kangawa

Journal:

Year:

2011

Language:

english

File:

PDF, 261 KB

english, 2011

19

Thyrotropin receptor gene expression in oncogene-transfected rat thyroid cells: Correlation between transformation, loss of thyrotropin-dependent growth, and loss of thyrotropin receptor gene expression

Maria Teresa Berlingieri, Takashi Akamizu, Alfredo Fusco, Michele Grieco, Glulla Colletta, Anna Maria Cirafici, Shoichiro Ikuyama, Leonard D. Kohn, Giancario Vecchio

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 560 KB

english, 1990

20

Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients

Shinji Kosugi, Toshiaki Ban, Takashi Akamizu, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 420 KB

english, 1991

21

Thyrotropin decreses leptin production in rat adipocytes

Mitsuyo Shintani, Haruo Nishimura, Takashi Akamizu, Shin Yonemitsu, Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda, Gen Inoue, Yasunao Yoshimasa, Kazuwa Nakao

Journal:

Year:

1999

Language:

english

File:

PDF, 1.09 MB

english, 1999

22

Characterization of the secretable ectodomain of thyrotropin receptor produced by the recombinant baculovirus system

Yoshiyuki Hattori, Takashi Akamizu, Misa Saijo, Naotetsu Kanamoto, Kenji Moriyama, Nobuyuki Ito, Kazuwa Nakao

Journal:

Molecular and Cellular Endocrinology

Year:

2001

Language:

english

File:

PDF, 213 KB

english, 2001

23

Association of Autoimmune Thyroid Disease with Microsatellite Markers for the Thyrotropin Receptor Gene and CTLA-4 in Japanese Patients

Akamizu, Takashi, Sale, Michéle M., Rich, Stephen S., Hiratani, Hitorni, Noh, Jaeduk Yoshimura, Kanamoto, Naotetsu, Saijo, Misa, Miyamoto, Yoshihiro, Saito, Yoshihiko, Nakao, Kazuwa, Bowden, Donald W.

Journal:

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

24

Numbness and paresthesia in bilateral toes and soles, and disproportional sweating restricted to face and trunk are suitable symptoms useful for the diagnosis of diabetic symmetric polyneuropathy

Muneki Nakatani, Hideyuki Sasaki, Seigo Kurisu, Hiroyuki Yamaoka, Shohei Matsuno, Kenichi Ogawa, Hiroshi Yamasaki, Hisao Wakasaki, Hiroto Furuta, Masahiro Nishi, Takashi Akamizu, Kishio Nanjo

Journal:

Journal of Diabetes Investigation

Year:

2011

Language:

english

File:

PDF, 127 KB

english, 2011

25

Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice

Masayuki Sugimoto, Hidenori Arai, Yukinori Tamura, Toshinori Murayama, Parinda Khaengkhan, Takuya Nishio, Koh Ono, Hiroyuki Ariyasu, Takashi Akamizu, Yukihiko Ueda, Toru Kita, Shigeharu Harada, Kaeko

Journal:

Atherosclerosis

Year:

2009

Language:

english

File:

PDF, 495 KB

english, 2009

26

Triiodothyronine effects on RNA polymerase activities in isolated neuronal and glial nuclei of the mature rat brain cortex

Hirotoshi Nakamura, Toshihiko Yokota, Takashi Akamizu, Toru Mori, Hiroo Imura

Journal:

Year:

1987

Language:

english

File:

PDF, 513 KB

english, 1987

27

Thyroid Hormone Action Is Disrupted by Bisphenol A as an Antagonist

Moriyama, Kenji, Tagami, Tetsuya, Akamizu, Takashi, Usui, Takeshi, Saijo, Misa, Kanamoto, Naotetsu, Hataya, Yuji, Shimatsu, Akira, Kuzuya, Hideshi, Nakao, Kazuwa

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2002

Language:

english

File:

PDF, 184 KB

english, 2002

28

Ultrasonographic thyroid nodular findings in Japanese children

Nobuyuki Taniguchi, Naomi Hayashida, Hiroki Shimura, Noriyuki Okubo, Yasushi Asari, Takeshi Nigawara, Sanae Midorikawa, Kazuhiko Kotani, Shigeyuki Nakaji, Misa Imaizumi, Akira Ohtsuru, Takashi Akamizu

Journal:

Journal of Medical Ultrasonics

Year:

2013

Language:

english

File:

PDF, 194 KB

english, 2013

29

Separate Measurement of Plasma Levels of Acylated and Desacyl Ghrelin in Healthy Subjects Using a New Direct ELISA Assay

Akamizu, Takashi, Shinomiya, Toshiaki, Irako, Taiga, Fukunaga, Mikihiko, Nakai, Yoshihide, Nakai, Yoshikatsu, Kangawa, Kenji

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2005

Language:

english

File:

PDF, 574 KB

english, 2005

30

Establishment of a Novel Ghrelin-Producing Cell Line

Iwakura, Hiroshi, Li, Yushu, Ariyasu, Hiroyuki, Hosoda, Hiroshi, Kanamoto, Naotetsu, Bando, Mika, Yamada, Go, Hosoda, Kiminori, Nakao, Kazuwa, Kangawa, Kenji, Akamizu, Takashi

Journal:

Year:

2010

Language:

english

File:

PDF, 229 KB

english, 2010

31

Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway

Shimada, Takeshi, Furuta, Hiroto, Doi, Asako, Ariyasu, Hiroyuki, Kawashima, Hiromichi, Wakasaki, Hisao, Nishi, Masahiro, Sasaki, Hideyuki, Akamizu, Takashi

Journal:

Year:

2014

Language:

english

File:

PDF, 440 KB

english, 2014

32

Recombinant monoclonal thyrotropin-stimulation blocking antibody (TSBAb) established from peripheral lymphocytes of a hypothyroid patient with primary myxedema

Moriyama, K., Okuda, J., Saijo, M., Hattori, Y., Kanamoto, N., Hataya, Y., Matsuda, F., Mori, T., Nakao, K., Akamizu, Takashi

Journal:

Journal of Endocrinological Investigation

Year:

2003

Language:

english

File:

PDF, 93 KB

english, 2003

33

Generation of Transgenic Mice Overexpressing a Ghrelin Analog

Yamada, Go, Ariyasu, Hiroyuki, Iwakura, Hiroshi, Hosoda, Hiroshi, Akamizu, Takashi, Nakao, Kazuwa, Kangawa, Kenji

Journal:

Year:

2010

Language:

english

File:

PDF, 215 KB

english, 2010

34

Oxytocin and Dopamine Stimulate Ghrelin Secretion by the Ghrelin-Producing Cell Line, MGN3-1 in Vitro

Iwakura, Hiroshi, Ariyasu, Hiroyuki, Hosoda, Hiroshi, Yamada, Go, Hosoda, Kiminori, Nakao, Kazuwa, Kangawa, Kenji, Akamizu, Takashi

Journal:

Year:

2011

Language:

english

File:

PDF, 258 KB

english, 2011

35

Alterations of Plasma Ghrelin Levels in Rats with Lipopolysaccharide-Induced Wasting Syndrome and Effects of Ghrelin Treatment on the Syndrome

Hataya, Yuji, Akamizu, Takashi, Hosoda, Hiroshi, Kanamoto, Naotetsu, Moriyama, Kenji, Kangawa, Kenji, Takaya, Kazuhiko, Nakao, Kazuwa

Journal:

Year:

2003

Language:

english

File:

PDF, 280 KB

english, 2003

36

Efficacy of Ghrelin as a Therapeutic Approach for Age-Related Physiological Changes

Ariyasu, Hiroyuki, Iwakura, Hiroshi, Yamada, Go, Nakao, Kazuwa, Kangawa, Kenji, Akamizu, Takashi

Journal:

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

37

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

Ariyasu, Hiroyuki, Takaya, Kazuhiko, Hosoda, Hiroshi, Iwakura, Hiroshi, Ebihara, Ken, Mori, Kiyoshi, Ogawa, Yoshihiro, Hosoda, Kiminori, Akamizu, Takashi, Kojima, Masayasu, Kangawa, Kenji, Nakao, Kazu

Journal:

Year:

2002

Language:

english

File:

PDF, 201 KB

english, 2002

38

Genomic Structure and Characterization of the 5′-Flanking Region of the Human Ghrelin Gene

Kanamoto, Naotetsu, Akamizu, Takashi, Tagami, Tetsuya, Hataya, Yuji, Moriyama, Kenji, Takaya, Kazuhiko, Hosoda, Hiroshi, Kojima, Masayasu, Kangawa, Kenji, Nakao, Kazuwa

Journal:

Year:

2004

Language:

english

File:

PDF, 636 KB

english, 2004

39

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

Ariyasu, Hiroyuki, Takaya, Kazuhiko, Tagami, Tetsuya, Ogawa, Yoshihiro, Hosoda, Kiminori, Akamizu, Takashi, Suda, Michio, Koh, Toshikiyo, Natsui, Koshi, Toyooka, Shigetake, Shirakami, Gotaro, Usui, Ta

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 149 KB

english, 2001

40

Substantial Production of Ghrelin by a Human Medullary Thyroid Carcinoma Cell Line

Kanamoto, Naotetsu, Akamizu, Takashi, Hosoda, Hiroshi, Hataya, Yuji, Ariyasu, Hiroyuki, Takaya, Kazuhiko, Hosoda, Kiminori, Saijo, Misa, Moriyama, Kenji, Shimatsu, Akira, Kojima, Masayasu, Kangawa, Ke

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 208 KB

english, 2001

41

Plasma acylated ghrelin levels correlate with subjective symptoms of functional dyspepsia in female patients

Shinomiya, Toshiaki, Fukunaga, Mikihiko, Akamizu, Takashi, Irako, Taiga, Yokode, Masayuki, Kangawa, Kenji, Nakai, Yoshihide, Nakai, Yoshikatsu

Journal:

Scandinavian Journal of Gastroenterology

Year:

2005

Language:

english

File:

PDF, 92 KB

english, 2005

42

Clinical significance of elevated labeled TSH binding (LTB) activity in sera of patients with Graves’ disease and other thyroid disorders

Takashi Akamizu M.D.,T. Mori,H. Ishii…

Journal:

Journal of Endocrinological Investigation

Year:

1987

Language:

english

File:

PDF, 648 KB

english, 1987

43

Immunoglobulin G That Interferes with Thyroid-Stimulating Antibody Measurements Can Be Eliminated Specifically by Incubation with Synthetic Peptides Corresponding to Partial Sequences of the Human Thyrotropin Receptor

UEDA, YOSHIMICHI, SUGAWA, HIDEO, AKAMIZU, TAKASHI, OKUDA, JYOJI, KIHO, YUKIO, MORI, TORU

Journal:

Year:

1993

Language:

english

File:

PDF, 3.13 MB

english, 1993

44

Diagnostic Criteria, Clinical Features, and Incidence of Thyroid Storm Based on Nationwide Surveys

Akamizu, Takashi, Satoh, Tetsurou, Isozaki, Osamu, Suzuki, Atsushi, Wakino, Shu, Iburi, Tadao, Tsuboi, Kumiko, Monden, Tsuyoshi, Kouki, Tsuyoshi, Otani, Hajime, Teramukai, Satoshi, Uehara, Ritei, Naka

Journal:

Year:

2012

Language:

english

File:

PDF, 1.31 MB

english, 2012

45

Identification of independent risk loci for Graves’ disease within the MHC in the Japanese population

Nakabayashi, Kazuhiko, Tajima, Atsushi, Yamamoto, Ken, Takahashi, Atsushi, Hata, Kenichiro, Takashima, Yasuo, Koyanagi, Midori, Nakaoka, Hirofumi, Akamizu, Takashi, Ishikawa, Naofumi, Kubota, Sumihisa

Journal:

Journal of Human Genetics

Year:

2011

Language:

english

File:

PDF, 386 KB

english, 2011

46

Molecular Basis for the Autoreactivity Against Thyroid Stimulating Hormone Receptor

Kohn, Leonard D., Kosugi, Shinji, Ban, Toshiaki, Saji, Motoyasu, Ikuyama, Shoichiro, Giuliani, Cesidio, Hidaka, Akinari, Shimura, Hiroki, Akamizu, Takashi, Tahara, Kazuo, Moriarty, John, Prabhakar, Be

Journal:

International Reviews Of Immunology

Year:

1992

Language:

english

File:

PDF, 2.11 MB

english, 1992

47

Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease

Morita, Mami, Watanabe, Mikio, Inoue, Naoya, Inaoka, Chisa, Akamizu, Takashi, Tatsumi, Ke-Ita, Hidaka, Yoh, Iwatani, Yoshinori

Journal:

Year:

2012

Language:

english

File:

PDF, 124 KB

english, 2012

48

Increased arterial stiffness is closely associated with hyperglycemia and improved by glycemic control in diabetic patients

Ibata, Junko, Sasaki, Hideyuki, Hanabusa, Tadashi, Wakasaki, Hisao, Furuta, Hiroto, Nishi, Masahiro, Akamizu, Takashi, Nanjo, Kishio

Journal:

Journal of Diabetes Investigation

Year:

2013

Language:

english

File:

PDF, 185 KB

english, 2013

49

Combination therapy with gefitinib and doxorubicin inhibits tumor growth in transgenic mice with adrenal neuroblastoma

Kawano, Kumi, Hattori, Yoshiyuki, Iwakura, Hiroshi, Akamizu, Takashi, Maitani, Yoshie

Journal:

Cancer Medicine

Year:

2013

Language:

english

File:

PDF, 3.23 MB

english, 2013

50

The Extracellular Domain of the TSH Receptor Has an Immunogenic Epitope Reactive with Graves' IgG but Unrelated to Receptor Function as Well as Determinants Having Different Roles for High Affinity TSH Binding and the Activity of Thyroid-Stimulating Autoantibodies

KOSUGI, SHINJI, AKAMIZU, TAKASHI, TAKAI, OSAMU, PRABHAKAR, BELLUR S., KOHN, LEONARD D.

Journal:

Year:

1991

Language:

english

File:

PDF, 3.85 MB

english, 1991

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